With the Joker: Folie à Deux trailer out in the wild, and fans already going nuts for Lady Gaga as Harley Quinn, the theories are already spinning over what might unfold in the highly-anticipated sequel from director Todd Phillips.

The madcap trailer features Joker and Harley seemingly making a break from Arkham Aslyum where the two of them are both inmates. This is a significant departure from the comics where Harley was originally a psychiatrist at the facility before being seduced by the Clown Prince of Crime. That departure from the source material has some people convinced that the Joker sequel might take another big swing with their relationship.