MILAN, March 6 — Daniele De Rossi’s reborn Roma will face their biggest night yet tomorrow when his friend Roberto De Zerbi returns to Italy with Brighton and Hove Albion for an intriguing Europa League last-16 tie.

In less than two months since taking over from Jose Mourinho, De Rossi has turned his boyhood club’s season around with passage past old foes Feyenoord in the competition’s play-offs and a sudden burst of form in Serie A.