(Video courtesy of The Drew Barrymore Show)

Over the last few years, Rob Lowe's son John Owen has poked fun at his famous father by replacing his face with John Stamos' in multiple family snapshots on Instagram.

Now, with a little help from Drew Barrymore, Stamos set the record straight on his supposed connection to the Lowe family — and who's really more attractive between him and Rob — by making a surprise appearance during Rob and John Owen's interview on The Drew Barrymore Show on Thursday.