Nina Griscom, a model, television host, fashion plate, columnist and entrepreneur who came to be known as an “It” girl in the high society whirl of 1980s New York, died on Saturday at her home in Manhattan. She was 65.

The cause was complications of amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease, which was diagnosed in late 2017, said Kelly Breheny, her personal assistant.