(Reuters) - Novak Djokovic will launch his bid to complete the calendar-year Grand Slam at the U.S. Open against a qualifier, but his path gets much tougher with potential clashes against Matteo Berrettini and Alexander Zverev.

French Open runner-up and third seed Stefanos Tsitsipas will take on former champion Andy Murray in the pick of the first round matches. Murray is now ranked 114th in the world as he has struggled to regain full fitness after undergoing hip re-surfacing surgery in 2019.