Former world number one Daniil Medvedev was once again drawn into a heated exchange with an umpire before crashing out of the Monte Carlo Masters following a 6-3 7-5 defeat by fellow Russian Karen Khachanov in the last 16 on Thursday.

Fourth seed Medvedev, who had reached at least the quarter-finals in the last two editions at Monte Carlo, never truly got going against Khachanov.